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Real members of MyNarcolepsyTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Nuvigil- Will I For Sure Eventually Need To Add Medications?

A MyNarcolepsyTeam Member asked a question 💭
Overland Park, KS

I have read many stories online of people doing well on Nuvigil for awhile, but then as time goes on having to add a "booster" medication halfway through the day. I want to know if I should expect this, or not. Has anyone been on Nuvigil for a long time with no decrease in effectiveness? Some sources also suggest taking a couple days off the medicine to curb resistance. Has anyone had experience with that?

May 26, 2020
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Answer Summary

Members shared mixed experiences with Nuvigil's long-term effectiveness, with some reporting the medication lost its potency after periods... Read more

Members shared mixed experiences with Nuvigil's long-term effectiveness, with some reporting the medication lost its potency after periods ranging from two weeks to several years, often requiring the addition of a stimulant like Adderall to maintain wakefulness throughout the day. Several members described their own medication journeys, including dosage increases and combination therapies, with one member noting that after 12 years on both Nuvigil and Adderall, the medications still work well though effectiveness can vary based on daily activity level. A recurring theme was the body's tendency to build tolerance to medications over time, with members emphasizing the importance of working closely with doctors to find the right combination and staying informed about treatment options.

A MyNarcolepsyTeam Member

I have talked with several doctors about several maladies, and the common thread, so far - for me, seems to be this: The human body acclimates to a particular medication. Its effectiveness decreases over time. Also, a negative side effect of a long-term medication can become permenant if the med is taken too long. Talk with your applicable doctor. Each medicine and its side effects is different. You, the patient, are responsible for researching these meds (and proposed meds) and selecting the one that offers the best results with the least side effects. Results and side effects can not be 'set in stone' because each of us is different.

June 30, 2020
A MyNarcolepsyTeam Member

I have taken Nuvigil & Adderall for around 12+ years now. They both work good still, but it also depends on what I'm doing that day & how active I am. Also it doesn't matter sometimes if I've taken my meds or not if I sit still for a too long I will be snoozing!

February 7, 2022
A MyNarcolepsyTeam Member

I was told 30mg capsules 2 times a day was the max....I live in Washington state.

August 25, 2020
A MyNarcolepsyTeam Member

Usually one needs a stimulant or how else can you be alert. Yes your body can get amune to it that it's not so affective. Just recently my doctor was going to put me on Wakix- a prescription medicine for narcolepsy. It is not a stimulant. What it does is increases the levels of histamine in the brain. A natural chemical that is important for wakefulness. Your insurance has to aprove it. Mine didn't. Its for adults only and people with liver or kidney disease shouldn't take it. My doctor wanted me to try it so that I'm better awake during the day so that to see if my sleep gets better at night. Anyone hear of this? I believe new.

August 24, 2020 (edited)
A MyNarcolepsyTeam Member

Agree

July 21, 2020

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