Anafranil (Clomipramine) for Narcolepsy | MyNarcolepsyTeam

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Anafranil is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat obsessions and compulsions in people with obsessive-compulsive disorder (OCD). Anafranil is sometimes prescribed off-label to treat narcolepsy. Anafranil is also known by its drug name, clomipramine.

Anafranil belongs to a class of drugs called tricyclic antidepressants. Tricyclic antidepressants are used to control narcolepsy symptoms like cataplexy, sleep paralysis and hypnagogic hallucinations. Anafranil is believed to work by changing the balance of neurotransmitters in the brain.

How do I take it?
Anafranil is taken once per day before bedtime.

Anafranil comes in capsule form.

Side effects
The FDA-approved label for Anafranil lists common side effects including dizziness, drowsiness, dry mouth, constipation, stomach upset, nausea, increased appetite, weight gain, sweating, fatigue, visual changes, and sexual dysfunction.

Rare but serious side effects listed for Anafranil include suicidal thoughts and behaviors, seizure, psychotic episodes, mania, severe skin rash, low white blood cells, low platelet count, and low red blood cell count (anemia).

For more details about this treatment, visit:

Anafranil — Mallinckrodt Pharmaceuticals

Anafranil — RxList

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