Tofranil (Imipramine) for Narcolepsy | MyNarcolepsyTeam

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Tofranil is a prescription drug approved by the Food and Drug Administration (FDA) to treat depression. Tofranil is sometimes prescribed off-label to treat narcolepsy. Tofranil may also be referred to by its drug name, imipramine.

Tofranil belongs to a class of drugs called antidepressants. Tofranil is believed to work in cases of narcolepsy by increasing transmission between neurons, increasing attention and alertness.

How do I take it?
Prescribing information states that Tofranil is taken once daily at nighttime or in divided doses.

Tofranil comes in capsule form. It should be taken exactly as prescribed by a physician.

Side effects
The FDA-approved label for Tofranil lists common side effects including heart problems, psychiatric issues such as insomnia or confusion, tingling, weakness, lack of coordination, dry mouth, nausea, vomiting, constipation, diarrhea, vision changes, ringing in the ears, decreased sex drive, and impotence.

Rare but serious side effects listed for Tofranil include suicidal ideation, panic attacks and anxiety, hyperactivity or agitation, aggression, serious heart problems including stroke and heart failure, serotonin syndrome (the accumulation of serotonin in the body, which can be life-threatening), and glaucoma.

For more details about this treatment, visit:

Tofranil — RxList

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