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... Antidepressants sometimes prescribed off-label to treat type 1 narcolepsy include: Clomipramine (Anafranil) Fluoxetine (Prozac) Protriptyline hydrochloride Venlafaxine (Effexor XR) 6. Good Sleep Hygiene Most doctors recommend a combination of medication and lifestyle changes to treat narcolepsy. ...

... Cataplexy medications include: Antidepressants like fluoxetine (Prozac) and venlafaxine (Effexor) — These medications help prevent cataplexy by reducing rapid eye movement (REM) sleep, the stage of sleep in which cataplexy symptoms are more likely to happen. They also adjust levels of serotonin and norepinephrine. ...

... For example, in a case study of a 22-year-old with narcolepsy, treatment with modafinil (Provigil) and venlafaxine (Effexor) triggered more severe manic episodes linked to bipolar disorder.7. DiabetesNarcolepsy may raise the risk of metabolic conditions like diabetes. ...